Formulation And Characterization Of Buccal Film Nanoemulsion Apigenin As Antidiabetic
نویسندگان
چکیده
Apigenin (4`,5,7-trihydroxyflavone) is a flavonoid of subclass flavones that have antidiabetic therapeutic activity but limitations BCS Class II low solubility 2.16 μg/L. To overcome these limitations, the development nanoemulsion formulation technology, increasing increases dissolution, absorption and bioavailability. It incorporated into buccal film for easy application direct access to systemic circulation. This study aims obtain apigenin with best characterization meets characterization. The method was carried out experimentally in manufacture nanoemulsions by spontaneous emulsification, solvent casting, 10 formulas met globule size <20.34nm, polydispersity index <0.131, zeta potential close 0mV, pH 6.23- 6.59, %transmittance 100% F10 has 29x compared p≤0.05. All films F3 having 2x faster onset release than F1&F2 86.07% diffusion 97.9333 mg/sheet. Thus, it concluded fulfilled increased 29-fold release.
منابع مشابه
Characterization of rice bran wax policosanol and its nanoemulsion formulation
Policosanol, a mixture of long-chain alcohols found in animal and plant waxes, has several biological effects; however, it has a bioavailability of less than 10%. Therefore, there is a need to improve its bioavailability, and one of the ways of doing this is by nanoemulsion formulation. Different droplet size distributions are usually achieved when emulsions are formed, which solely depends on ...
متن کاملsynthesis and characterization of some macrocyclic schiff bases
ماکروسیکلهای شیف باز از اهمیت زیادی در شیمی آلی و دارویی برخوردار می باشند. این ماکروسیکلها با دارابودن گروه های مناسب در مکانهای مناسب می توانند فلزاتی مثل مس، نیکل و ... را در حفره های خود به دام انداخته، کمپلکسهای پایدار تولید نمایند. در این پایان نامه ابتدا یک دی آلدئید آروماتیک از گلیسیرین تهیه می شود و در مرحله بعدی واکنش با دی آمینهای آروماتیک و یا آلیفاتیک در رقتهای بسیار زیاد منجر به ت...
15 صفحه اولNew formulation and approach for mucoadhesive buccal film of rizatriptan benzoate
Mucoadhesive buccal film is developed as a promising dosage form, which has prominent advantages because of drug delivery through buccal mucosa. New formulation of buccal films containing rizatriptan benzoate (RB) was prepared by solvent casting method using various concentrations of hydroxypropyl methylcellulose (HPMC K4M), polyvinyl alcohol (PVA), polyethylene oxide (PEO), glycerol, stevia, a...
متن کاملFormulation and Evaluation of Nitrendipine Buccal Films
A mucoadhesive drug delivery system for systemic delivery of nitrendipine, a calcium channel blocker through buccal route was formulated. Mucoadhesive polymers like hydroxypropylmethylcellulose K-100, hydroxypropylcellulose, sodium carboxymethylcellulose, sodium alginate, polyvinyl alcohol, polyvinyl pyrrolidone K-30 and carbopol-934P were used for film fabrication. The films were evaluated for...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: IJPST (Indonesian Journal Pharmaceutival Science and Technology)
سال: 2022
ISSN: ['2356-1971', '2406-856X']
DOI: https://doi.org/10.24198/ijpst.v1i1.42829